Pipeline

RNA therapeutics for complex diseases

At Nutcracker Therapeutics, we are driven by the unique opportunity that RNA offers to develop best-in-class medicines that will improve human health around the world. Because the promise of RNA isn’t the future, it’s now.

Pipeline

Program

Program

Discovery

Lead candidate identification

IND-enabling studies

Phases 1-3

NTX-250

Target

HPV16 E6/E7, IL-12, LIGHT

Modality

Locally delivered, mRNA encoded immunotherapy with engineered LIGHT +IL-12

Indication

High-grade cervical dysplasia, HPV-driven tumors

Discovery Lead candidate identification IND-enabling studies Phases 1-3

NTX-470

Target

PSMA-STEAP1 T Cell engager

Modality

Systemically delivered, mRNA encoded multi-specific protein

Indication

Metastatic, castration resistant prostate cancer

Discovery Lead candidate identification IND-enabling studies Phases 1-3

NTX-472

Target

aCD19-aCD20-SIRPα

Modality

Systemically delivered, mRNA encoded multi-specific protein

Indication

Auto-immune disease; R/R B cell lymphoma

Discovery Lead candidate identification IND-enabling studies Phases 1-3