A complete platform for RNA therapeutics

Mix innovative RNA design and chemistry with advanced nanoparticle delivery, then combine it with cutting-edge microfluidic engineering and proprietary biochip-based hardware, and you have the Nutcracker Therapeutics technology platform. The next wave of drug discovery and development is here.

Design Delivery Manufacturing

An end-to-end platform for RNA medicines under one roof

From design of RNA molecules during early research, to selection of optimal delivery vehicles, to GMP manufacturing for clinical trials and commercialization, the Nutcracker Therapeutics technology platform is designed to provide a complete solution for the advancement of RNA-based medicines.

The art and science of RNA design

Nutcracker Therapeutics’ proprietary, cloud-based CodonCracker™ software rapidly optimizes RNA sequences to fine-tune protein expression levels and manufacturability. Our RNA designs also incorporate novel sequence elements to further enhance the activity of our products.

Novel delivery vehicles

Nutcracker Therapeutics’ nanoparticle technology offers a growing library of unique and effective Nutshell® delivery vehicles, including thousands of tested formulations that have been evaluated across more than 200 compounds. Nutshell® delivery vehicles offer several advantages, including tunable chemical structures, uniform nanoparticle size, and low toxicity and immunogenicity.

Engineering meets biology in the Nutcracker® Manufacturing Unit (NMU)

The best path to realizing the promise of RNA therapeutics is the one that increases the speed and scale at which they can be discovered, developed, and manufactured. By combining biochip-based engineering principles with microfluidic design, we’ve created a single hardware system powered by process-specific biochips that takes RNA therapeutic manufacturing from DNA sequence to fully formulated nanoparticles on a versatile, software-controlled platform.

Scalable microfluidics

The Nutcracker® Manufacturing Unit utilizes a fully enclosed microfluidic path that requires minimal hands-on time. Our proprietary template, IVT, and formulation biochips allow for precise control, reproducibility, and scalability, and have integrated purification capabilities (template/IVT). These biochips are intended to support research, clinical, and commercial use.

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In-process biochip monitoring

Our consumable biochips with integrated process control features are at the core of the Nutcracker® Manufacturing Unit. Our proprietary active monitoring and novel closed loop process measurements are built directly into our biochips and designed to ensure quality and consistency across every manufacturing cycle.

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The automated processes of the Nutcracker® Manufacturing Unit are tightly controlled by proprietary integrated software. Our systems and processes are designed to fully incorporate the controls required for GMP manufacturing, resulting in highly consistent production of every lot of material.

Rapid cycle times

The automated nature of the Nutcracker® Manufacturing Unit makes it ideal for rapid iteration during the discovery and development of new therapeutics. The NMU is compatible with the production of both off-the-shelf and patient-specific RNA formulations, with the ability to go from patient sample to personalized drug product in as little as a few weeks.

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